Crimson Publishers- Novel Approaches in Cancer Study

Release of Inorganic Phosphate into the Tumor Environment: Possible Roles of Ecto- Nucleotidases and Ecto-Phosphatases by Marco Antonio Lacerda-Abreu and José Roberto Meyer- Fernandes in Journal of Cancer Research Crimson Publishers _  Novel Approaches in Cancer Study Inorganic phosphate (Pi) is essential for several biochemical reaction. Serum Pi is maintained at relatively narrow range concentrations, between 0.7 and 1.55mM. Tumor microenvironment presents a high Pi concentration (1.8±0.2mM Pi) and this could be associated wi the rapid growth in the “Growth Rate Hypothesis”. Several studies have identified high expression of Pi transporters in various tumor tissues. Similarly, ecto-enzymes (like ecto-nucleotidases or ecto- phosphates) act by dephosphorylating phosphosubstrates in the extracellular environment, and its high expression has been observed in various types of cancer. Little is known about the function of these ecto-enzymes on Pi releasing and accumulation in the tu...

Consensus or Controversy Should Mutational Analysis (Ma) Be Considered as a Routine Testing in the Clinical Management of Gastrointestinal Stromal Tumor (GIST) in the Era of Personalized Medicine? by Feng X in Journal of Cancer Research     Crimson Publishers_  Novel Approaches in Cancer Study Unique amongst most solid malignancies, gastrointestinal stromal tumors (GISTs) are addicted to a few specific oncogenic drivers and are uniformly resistant to cytotoxic chemotherapeutics but sensitive to tyrosine kinase inhibitors (TKIs). Similar to all cancers, GISTs are heterogenous and subclassified into distinct entities according molecular alterations. It is unquestionable that mutational status offers both prognostic as well as predictive value to guide clinical management of GISTs in both advanced/metastatic and curative/(neo)adjuvant settings. One would therefore assume that mutational analysis would be routine and adopted routinely in terms of timing in the clinical mana...

Change of Individual Weight of a Patient with Autoimmune Thyroiditis and Colon Cancer Before and After Treatment  by Zotin AA in Journal of Cancer Research   Crimson Publishers_  Novel Approaches in Cancer Study   Human growth, as a rule, is studied in the youthful period, limited to the first 20-30 years of life. This is largely due to the fact that a person’s linear growth in height ends by 18-22 years old Bogin [1]. A person’s weight reaches a maximum by 25-30 years Zotin [2]. However, a change in body mass occurs throughout life. In addition, growth is usually accompanied by biorhythms even during periods when changes in average body weight are not observed. The initial goal of the work was to identify growth biorhythms in adults measuring my weight for example. However, during the study, diseases that affect body weight were discovered. Accordingly, the purpose of the work has changed.   https://crimsonpublishers.com/nacs/fulltext/NACS.000566.php  ...