Crimson Publishers- Novel Approaches in Cancer Study

The Effects of Radiation on Cancer Immunology by Yi Lu in Journal of Cancer Research     Crimson Publishers: Novel Approaches in Cancer Study Cancer immunology largely depends on the effects of radiation therapy (RT). RT is predominantly focused on inducing tumor cell death, triggering anti-tumor immune responses, and generating DNA damage. Although the immune system has the ability to recognize and reject specific tumors, some tumors acquire characteristics that allow them to evade immune destruction by expressing a highly immunosuppressive microenvironment and decreasing their immunogenicity. Exposing the tumor site to radiation stimulates tumor-specific antigens, making them perceptible to the immune system and stimulating the priming and activation of cytotoxic T cells. In addition, tissue damage caused by radiation applied to the tumor microenvironment moderates a release of inflammatory cytokines that assists in leukocyte infiltration to the damage site and promotes an a...

The Role of Cyclin-Dependent Kinases on the Metastasis of Breast Cancer by Yi Lu in Journal of Cancer Research     Crimson Publishers Novel Approaches in Cancer Study Cyclin-Dependent kinases (CDKs) function in mitosis by allowing the cycle to progress from one stage to another due to their properties as a family of protein kinases. Because of this function, abnormalities with CDKs can lead to uncontrolled cell division, leading to diseases such as cancer. Breast cancer is one form of cancer in which CDKs are a prevalent area of study. The role CDKs play in controlling and coordinating cell division makes it an important process to understand in breast cancer and, specifically, the metastasis of breast cancer. Lack of controlled CDK function could allow the cancer to spread to other parts of the body, leading to metastasis. Inhibiting CDK activity is an area of interest in searching for ways to treat breast cancer, especially once it has spread to the point where tumors cann...