Targeting Telomerase and Topoisomerase-II by Natural Moieties: An Anti-Cancer Approach_Crimson Publishers

Targeting Telomerase and Topoisomerase-II by Natural Moieties: An Anti-Cancer Approach in Crimson Publishers: Journal of Cancer Research

 
Crimson Publishers_ Novel Approaches in Cancer Study

One of the fundamental characteristic of tumor cell is to maintain the telomere length for continues progressive growth and survival. For the same, tumor cell has elevated levels of telomerase enzyme[1]. Telomerase is an unusual enzyme that acts on parts of chromosomes known as telomeres. Telomerase is a ribonucleoprotein and expressed in approximately 85% of different human cancers[2]. There is strong evidence for the existence of an important relationship between telomeres, telomerase and cancer [3]. Normal human cells progressively lose telomeres with each cell division until a few short telomeres become uncapped leading to a growth arrest, known as replicative aging. This phenomenon is totally absent in the cancer and cancer cells are adapted to have higher levels of telomerase enzyme which results in uncontrolled cell division. Attempts have also been made to develop telomere length-and telomerase-based diagnostic tools and anticancer therapeutics [4].



Novel Approaches in Cancer Study: Crimson Publishers
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