Bridging the Gap between Pre-Clinical and Clinical Studies in Cancer Research_Crimson Publishers
Bridging the Gap between Pre-Clinical and Clinical Studies in Cancer Research by Ratna Kumari in Journal of Cancer Research
Crimson Publishers_ Novel Approaches in Cancer Study
In spite of successful basic and pre-clinical cancer research findings its translatability into clinics
is significantly low. Unfortunately, most of the clinical trials in oncology are unsuccessful and lead to
pharmacological drug attrition. The complex nature of cancer biology and limitations due to pre-clinical
research tools makes pre-clinical cancer research prone to irreproducibility. Pharmacological development
of drugs heavily relies on the published data for drug target biology and irreproducible findings
are the key factor behind high failure rates of clinical trials. Consequently, there is an urgent need to
revisit the pre-clinical cancer research strategies to achieve a greater clinical success.
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