The Acoustic Technology for Ctcs Isolation in Blood: Low-Cost Devices_Crimson Publishers
The Acoustic Technology for Ctcs Isolation in Blood: Low-Cost Devices by Itziar González in Journal of Cancer Research
Crimson Publishers_ Novel Approaches in Cancer Study
Blood samples can be used as a liquid biopsy in cancer diagnosis and chemotherapy monitoring. This label-
free method offers benefits over traditional tissue invasive biopsy. It is possible to separate rare cells
from blood samples by Ultrasounds on the basis of their physical properties in a biocompatible manner.
A successful separation of cultured cancer cells from WBCs with acoustic-based methods is being demonstrated
during the last years through different technological approaches. The concept of plate acoustic
waves (PAW) applied to acoustophoresis was recently introduced to perform acoustic flow-through separation
of rare cells in blood samples. It lies in the geometrical chip design, different to other micro separators
(BAW and SAW). This new strategy allows soft materials of extremely reduced volume and low-cost
fabrication and opens a door to printing manufacturing processes.
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