Cancer Stem Cells and the Unicellular Life Cycle of Cancer_Crimson Publishers

Cancer Stem Cells and the Unicellular Life Cycle of Cancer by Vladimir F Niculescu in Journal of Cancer Research

 

Crimson Publishers_ Novel Approaches in Cancer Study

All eukaryotes, from protists to mammalians, preserve a unicellular life cycle inherited from the common ancestor that can be reactivated under unfavorable living conditions. The cell-of-origin of cancer escapes its death by forming a protected polyploid cyst-like structure (CLS), that starts the unicellular life cycle of cancer. The reversal to unicellularity occurs through genomic and epigenetic alterations that activate the MUT switch of early Metazoans and not through mutations. The microcell progeny of CLSs spread into tissues and organs and form the CSC pool of aCLS cancers. Depending on the environment, the CSC pool differentiates a reproductive cell subline, which forms new aCLSs by cyclic encystment and asymmetric cell division, or a somatic subline, which proliferates strongly by symmetric cell division without cyst differentiation.  

https://crimsonpublishers.com/nacs/fulltext/NACS.000565.php 

please click on the link https://www.scilit.net/publisher/9410/10350

 

 

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