Iodine-125 Seed Combined with Stent Placement and Transarterial Chemoembolization for Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Systematic Review and Meta-Analysis

Iodine-125 Seed Combined with Stent Placement and Transarterial Chemoembolization for Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Systematic Review and Meta-Analysis by Wei Fan Sui in Novel Approaches in Cancer Study

Abstract

Background: Portal vein tumor thrombus plays an important role in indicating the poor prognosis of hepatocellular carcinoma.
Purpose: To assess the safety and efficiency of iodine-125 seed combined with stent placement and transarterial chemoembolization for treatment of hepatocellular carcinoma with portal vein tumor thrombosis.
Materials and methods: We searched Cochrane library, PubMed, EMBASE, CNKI, Wang fang Data and CQVIP. We assessed the qualities of included studies. We analyzed the characteristic data, tested heterogeneity, explored heterogeneity and tested publication bias by software-Review Manger 3.5.
Result: Totally 7 clinical controlled trials were selected with the inclusion criterion. The results showed that the pressure of main portal vein after stent placement was significantly lower than no stent placement. The cumulative stent patency rates and survival rates in 6 and 12 months of iodine-125 seed combined with stent placement and transarterial chemoembolization were higher than conventional transarterial chemoembolization, transarterial chemoembolization combined with stent and 3-dimensional conformal radiotherapy.
Conclusion: For hepatocellular carcinoma patients with portal vein tumor thrombosis, iodine-125 seed combined with stent placement and transarterial chemoembolization was safety. The efficiency of iodine-125 seed combined with stent placement and transarterial chemoembolization were better than conventional transarterial chemoembolization, transarterial chemoembolization plus stent and transarterial chemoembolization combined with stent and 3-dimensional conformal radiotherapy.

Read more about this article:

https://crimsonpublishers.com/nacs/fulltext/NACS.000665.php


Comments

Post a Comment

Popular posts from this blog

Recent Advances in the Therapeutic Approaches of Glioblastoma Multiforme_Crimson Publishers

Image
  Recent Advances in the Therapeutic Approaches of Glioblastoma Multiforme by Siddharth Shah in  in Novel Approaches in Cancer Study Abstract Glioblastoma Multiforme (GBM, WHO grade IV) is one of the most aggressive, invasive, and lethal intracranial neoplasms, with a low post-diagnosis survival rate. Standard-of-care treatment regimens involving maximal surgical resection, radiotherapy, and genetic anti-tumor compounds like Temozolomide have only been marginally effective in improving overall survival and quality of life. Cell fusion, autophagy, and other complex biological processes affecting GBM pathophysiology are being studied to improve GBM treatment. This paper therefore focuses on oncolytic virus therapy combined with surgical resection, photodynamic therapy, and novel gene therapy, demonstrating how GBM treatment for patients could result in immediate and authentic tumor cytotoxicity and removal, rather than treatment of recurrent GBM. Standard therapy for GBM,...
Read more

Release of Inorganic Phosphate into the Tumor Environment: Possible Roles of Ecto- Nucleotidases and Ecto-Phosphatases

Abstract Inorganic phosphate (Pi) is essential for several biochemical reaction. Serum Pi is maintained at relatively narrow range concentrations, between 0.7 and 1.55mM. Tumor microenvironment presents a high Pi concentration (1.8±0.2mM Pi) and this could be associated wi the rapid growth in the “Growth Rate Hypothesis”. Several studies have identified high expression of Pi transporters in various tumor tissues. Similarly, ecto-enzymes (like ecto-nucleotidases or ecto- phosphates) act by dephosphorylating phosphosubstrates in the extracellular environment, and its high expression has been observed in various types of cancer. Little is known about the function of these ecto-enzymes on Pi releasing and accumulation in the tumor environment. Therefore, the purpose of this study is to correlate a possible contribution of the Pi release in the tumor microenvironment by ecto-nucleotidases and ecto-phosphatases, concomitant to the regulation of Pi extracellular pool by specific Pi...
Read more

Release of Inorganic Phosphate into the Tumor Environment: Possible Roles of Ecto- Nucleotidases and Ecto-Phosphatases_Crimson Publishers

Image
Release of Inorganic Phosphate into the Tumor Environment: Possible Roles of Ecto- Nucleotidases and Ecto-Phosphatases by Marco Antonio Lacerda-Abreu and José Roberto Meyer- Fernandes in Journal of Cancer Research Crimson Publishers _  Novel Approaches in Cancer Study Inorganic phosphate (Pi) is essential for several biochemical reaction. Serum Pi is maintained at relatively narrow range concentrations, between 0.7 and 1.55mM. Tumor microenvironment presents a high Pi concentration (1.8±0.2mM Pi) and this could be associated wi the rapid growth in the “Growth Rate Hypothesis”. Several studies have identified high expression of Pi transporters in various tumor tissues. Similarly, ecto-enzymes (like ecto-nucleotidases or ecto- phosphates) act by dephosphorylating phosphosubstrates in the extracellular environment, and its high expression has been observed in various types of cancer. Little is known about the function of these ecto-enzymes on Pi releasing and accumulation in the tu...
Read more